It seems there is some problem rendering the layout during design time. Some property is probably unitiliazed but I can't tell more. You can send us your app to info@radzen.com and we will investigate further. You can probably skip rendering the layout as a temporary workaround via the layout switch in the toolbar:
Even more, I have some simpler layout page and in a routes page I changed to this one but nothing really happened. Then I left Blazor Studio and opened it again. After that I opened one of the scaffolded pages and received this. Interesting is that the layout is Failed to get layouts.
Well this one is too large to be sent so I made a small one with the same problem. This is 100% scaffolded by Blazor Studio except that I add some files with the intention to obtain Cascading Parameter features. And of course, this one too can be compiled and executed.