Disable certain dates in datePicker widget

Would it be possible to disable some days in the datePicker?
I plan to create a mask in which the user can choose 3 periods in 3 date-range-pickers.
When the user reaches the second picker he should not be able to select any day which he already selected in the first control.

No, this isn't supported yet. The PrimeNG datepicker supports disabled dates and disabled days (e.g. Monday, Tuesday etc). We can probably expose that in a future Radzen release.